Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery

Recruiting now · Not applicable

Conditions studied: Postoperative Delirium (POD), Postoperative Pain, PONV, Burst Suppression, Recovery Period, Anesthesia

In brief

This study aims to investigate the effect of target-controlled infusion using the Eleveld pharmacokinetic model compared with manually controlled total intravenous anesthesia on the incidence of postoperative delirium in patients undergoing supratentorial surgery. Propofol and remifentanil are administered using either target-controlled or manual infusion techniques according to the study protocol. Secondary objectives include comparisons of intraoperative anesthetic consumption, hemodynamic responses, recovery profiles, postoperative pain, and postoperative nausea and vomiting between the two anesthesia strategies. The study seeks to evaluate whether target-controlled infusion provides improved anesthetic management and postoperative outcomes compared with manual total intravenous anesthesia.

Key facts

Study ID

NCT07357480

Run by

Istanbul University - Cerrahpasa

People needed

70

Starts

2026-01-14

Expected to finish

2026-05-01

Last updated by the study team

2026-03-25

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients aged 18 to 60 years
• Scheduled for elective supratentorial surgery under general anesthesia
• American Society of Anesthesiologists (ASA) physical status I or II
• Planned total intravenous anesthesia with propofol and remifentanil
• Ability to provide written informed consent

You may not qualify if…

• Refusal or inability to provide written informed consent
• American Society of Anesthesiologists (ASA) physical status III or higher
• Pregnancy
• Emergency surgery
• Presence of brain herniation
• Anticipated or documented difficult airway
• Inability to communicate effectively (e.g., non-Turkish speaking or hearing impairment)
• Preoperative risk factors for delirium, including substance abuse, use of neuropsychiatric medications, preoperative hemoglobin level < 8 g/dL, malnutrition, or electrolyte or thyroid hormone abnormalities
• Intraoperative deviation from the study protocol, including changes in surgical or anesthetic technique or occurrence of major intraoperative complications
• Contraindications to propofol or remifentanil

Where it is running

• Cerrahpaşa Tıp Fakültesi Murat Dilmener Hastanesi — Istanbul, Istanbul, Turkey (Türkiye) (enrolling)
• Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine — Istanbul, Bakırköy, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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