Carbon Dioxide Administration and Brain Waste Clearance
Recruiting now · Not applicable
Conditions studied: Traumatic Brain Injury, Aging Disorder, Magnetic Resonance Imaging (MRI)
In brief
The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood. The investigators believe that this would be a proxy for the brain clearing waste products more effectively. The current study will use a counter-balanced design, in which individuals with and without a history of traumatic brain injury (TBI) will receive different levels of CO2 (targeted changes of approximately 5 or 10 mmHG in end-tidal CO2) approximately one week apart. The counter-balanced design means that each participant receives a single dose of CO2 at each visit, and different doses of CO2 at each visit. The order in which participants receive the dose is randomized, and the participant will not be informed of the dose.
Key facts
- Study ID
- NCT07357090
- Run by
- Andrew Mayer
- People needed
- 200
- Starts
- 2026-04-01
- Expected to finish
- 2032-02-01
- Last updated by the study team
- 2026-02-23
Who can join
Age: 18 and older, up to 82. Sex: any. Healthy volunteers: accepted.
Where it is running
- The Mind Research Network — Albuquerque, New Mexico, United States (enrolling)
Full record on ClinicalTrials.gov
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