Verifying Antibodies After Live Immunization Delivery (VALID): A Study of Measles Vaccine Immunogenicity in Children With Sickle Cell Disease

Recruiting now

Conditions studied: Sickle Cell Disease, Measles Vaccination, Sickle Cell Anemia

In brief

The goal of this study is to learn if infants with sickle cell disease (SCD) develop adequate protection after measles vaccines. (not looking at any prolonged duration)

Key facts

Study ID

NCT07356050

Run by

Children's Hospital Medical Center, Cincinnati

People needed

130

Starts

2025-03-13

Expected to finish

2028-12-31

Last updated by the study team

2026-01-21

Who can join

Age: 1 and older, up to 6. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants with confirmed Sickle Cell Disease.
• Participants 6 months and 6 years of age and due for measles vaccination within 3 months per national guidelines.
• Willing and able to provide informed consent
• Ability to comply with study related evaluations and follow-up visits.

You may not qualify if…

• Known primary immunodeficiency syndrome, cancer, or acquired immunodeficiency syndrome (AIDS) that would preclude vaccination with live virus vaccines.

Where it is running

• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States (enrolling)
• Korle Bu Teaching Hospital — Accra, Ghana, Ghana (enrolling)
• Bugando Medical Centre — Mwanza, Tanzania (enrolling)

Full record on ClinicalTrials.gov

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