Study to Evaluate the Efficacy of an Avocado Dietary Supplement

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: Overweight, Metabolic Health, Insulin Resistance

In brief

This 16-week, randomized, triple-blinded, placebo-controlled study evaluates the effects of an avocado dietary supplement (Metavo) on healthy weight and blood glucose management in overweight adults. The study includes body measurements, questionnaires, blood tests, and CGM monitoring to assess metabolic outcomes and participant-reported perceptions of well-being.

Key facts

Study ID

NCT07354308

Run by

SP Nutraceuticals Inc.

People needed

60

Starts

2025-05-01

Expected to finish

2026-01-01

Last updated by the study team

2026-01-21

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Be male or female
• Be aged between 18 and 70 years of age
• Be classified as overweight or obese with a BMI of ≥25.0 and ≤32 kg/m2.
• Have a stable weight defined as <10% change in body weight in three months prior to the study start date.
• Willing to follow the provided diet and exercise guidelines.
• Willing to not consume avocados throughout the trial and for two weeks prior to Baseline
• Anyone who is generally healthy - does not live with any uncontrolled chronic disease.
• Willing to stop any products, any prescription medication, or supplements that target weight management, blood sugar control, and/or aim to improve insulin during the test period.
• Willing to avoid introducing any new products or any new forms of prescription medication or supplements that target weight management, blood sugar control, and/or aim to improve insulin during the test period.
• Not currently partaking in another research study and will not be partaking in any other research study for the next 16 weeks and at any point during this study's duration.
• Must have someone available to take front and side profiles of the torso.
• Must have a smart phone or camera capable of taking photos of the torso.
• Resides in the United States.

You may not qualify if…

• Anyone with diagnosed Type I or Type II diabetes.
• Allergic to avocados
• Anyone with any allergies or sensitivities to any of the study product ingredients.
• Any women who are pregnant, breastfeeding, or trying to conceive
• Anyone unwilling to follow the study protocol.
• Has stopped using hormonal birth control in the past month.
• Anyone with a history of substance abuse.
• Anyone who is currently a smoker or has been a smoker in the past 6 months.
• Anyone with chronic health conditions that could impact participation in the study, such as oncological, psychiatric, metabolic, hypertension, or cardiovascular disorders, cancer, autoimmune disease, HIV, Hepatitis B, and/or C, kidney and/or liver, gastrointestinal, gastroesophageal reflux, blood/bleeding disorders, gout, or mental health disorders.
• Anyone who has had any major illness in the last 3 months.
• Anyone who drinks heavily (i.e., 8 or more alcoholic drinks per week for women or 15 or more alcoholic drinks per week for men).
• Current use of prescribed medications as listed below: Weight loss prescription medication (within 3 months of baseline). Anticoagulants and coagulants (within 4 weeks of baseline).
• Anyone who has used any cannabis products (medical or recreational) in the past month.

Where it is running

• Citruslabs — Las Vegas, Nevada, United States

Full record on ClinicalTrials.gov

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