Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Osteoarthritis, Overweight or Obesity

In brief

The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening.

Key facts

Study ID

NCT07353931

Run by

Eli Lilly and Company

People needed

900

Starts

2026-02-09

Expected to finish

2028-05-01

Last updated by the study team

2026-08-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening
• Have a stable body weight (less than 5% body weight change) for 90 days prior to screening
• Have tried at least once to lose weight through diet but were unsuccessful
• Have osteoarthritis of the knee and at least one of the following conditions:
• Be over 50 years old
• Have morning knee stiffness that lasts about 30 minutes
• Have a crackling or grinding sound or feeling in the knee

You may not qualify if…

• Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening)
• Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
• Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
• Have an active knee infection
• Have had within 90 days prior to screening:
• heart attack
• stroke
• coronary artery revascularization
• unstable angina, or
• hospitalization due to congestive heart failure
• Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
• Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Where it is running

• Central States Research — Tulsa, Oklahoma, United States (enrolling)
• Elite Pain and Spine Institute - South Crimson Road — Mesa, Arizona, United States (enrolling)
• Care Access - 801 South Power Road, Mesa — Mesa, Arizona, United States (enrolling)
• AMR Clinical — Mobile, Alabama, United States (enrolling)
• Ark Clinical Research - Fountain Valley — Fountain Valley, California, United States (enrolling)
• Wolverine Clinical Trials — Santa Ana, California, United States (enrolling)
• Encompass Clinical Research — Spring Valley, California, United States (enrolling)
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States (enrolling)
• Tucson Orthopaedic Institute - North Wyatt Drive — Tucson, Arizona, United States (enrolling)
• Westside Center for Clinical Research — Jacksonville, Florida, United States (enrolling)
• Care Access - St. Petersburg — St. Petersburg, Florida, United States (enrolling)
• Conquest Research — Winter Park, Florida, United States (enrolling)
• Orita Clinical Research — Decatur, Georgia, United States (enrolling)
• Medical Research Partners — Ammon, Idaho, United States (enrolling)
• Great Lakes Clinical Trials - Ravenswood — Chicago, Illinois, United States (enrolling)
• Qualmedica Research, LLC — Evansville, Indiana, United States (enrolling)
• AMR Clinical — Newton, Kansas, United States (enrolling)
• Monroe Biomedical Research - Louisville — Louisville, Kentucky, United States (enrolling)
• Skylight Health Research - Burlington — Burlington, Massachusetts, United States (enrolling)
• Care Access - Quincy — Quincy, Massachusetts, United States (enrolling)
• Ellipsis Research Group - Brooklyn - 7th Street — Brooklyn, New York, United States (enrolling)
• Rochester Clinical Research - Buffalo — Buffalo, New York, United States (enrolling)
• NYC Research INC — Long Island City, New York, United States (enrolling)
• Rochester Clinical Research, LLC — Rochester, New York, United States (enrolling)
• Keystone Clinical Studies — Plymouth Meeting, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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