Effect of Intermittent Enteral Feeding in Severe Stroke

Starting soon · Not applicable

Conditions studied: Severe Stroke, Enteral Nutrition

In brief

This is a single-center, randomized, exploratory clinical trial investigating whether intermittent enteral feeding improves outcomes compared to continuous feeding in patients with severe stroke. The study will enroll 60 patients to evaluate the impact on 90-day all-cause mortality, neurological function, nutritional status, and safety. It will also explore underlying mechanisms through analysis of metabolic profiles, circadian gene expression, and gut microbiota.

Key facts

Study ID

NCT07353658

Run by

Xijing Hospital

People needed

60

Starts

2026-01-05

Expected to finish

2026-12-31

Last updated by the study team

2026-01-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years old
• It was definitely diagnosed as acute stroke by clinical imaging.
• Enteral nutrition program can be started within 72 hours of onset.
• Baseline GCS≤12 or NIHSS≥11
• There is nutritional risk (NRS 2002≥3), Wadian drinking water test≥ 3 or there is consciousnessdisorder,it is estimated that you need to receive nutritional support treatment for ≥7 days
• Obtain informed consent

You may not qualify if…

• Before joining the group, he had received total parenteral nutrition treatment.
• There are contraindications to enteral nutrition.
• Unstable vital signs
• Dementia or severe disability before onset (mRS≥3)
• There are concomitant diseases that will interfere with outcome evaluation and/or follow-up.
• Participating in other interventional clinical trials.
• Other circumstances in which the study cannot be completed.

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.