Shanghai Clinical Cohort - Parkinson's Disease (Reserve)
Recruiting now
Conditions studied: Parkinson's Disease (PD), Multiple System Atrophy
In brief
The goal of this observational cohort studyis to establish a high-quality clinical cohort of Parkinson's disease (PD) and multiple system atrophy (MSA) patients in Shanghai, in order to improve early diagnosis, precise subtyping, disease monitoring, and to provide a resource for translational research and novel therapy development. The main questions it aims to answer are: * Can multimodal data (clinical, imaging, electrophysiology, biospecimens, and genetics) help identify early biomarkers for PD and MSA? * Can precise subtyping and long-term monitoring predict disease progression and therapeutic response? Researchers will compare 600 PD patients and 100 MSA patients to evaluate differences in clinical features, biomarkers, imaging, and prognosis. Participants will: * Provide informed consent and complete baseline demographic and medical history collection. * Undergo standardized clinical evaluations, including motor and non-motor symptom scales, cognitive and quality-of-life assessments. * Provide biological samples (blood, saliva, optional CSF). * Receive brain imaging (MRI, optional PET/SPECT) and electrophysiological recordings (EEG, fNIRS). * Participate in longitudinal follow-up visits every 6 months for repeat assessments. This study will create a sustainable, multicenter, and sharable cohort platform to support early identification, personalized intervention, and therapeutic development for neurodegenerative diseases
Key facts
- Study ID
- NCT07353463
- Run by
- Ruijin Hospital
- People needed
- 700
- Starts
- 2025-04-01
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-03-05
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine — Shanghai, China (enrolling)
Full record on ClinicalTrials.gov
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