The Effect of Blood Carboxyhemoglobin Levels on NF-kB, NRF2 and PGC-1α During Low-flow and Normal-flow Anesthesia

Recruiting now · Not applicable

Conditions studied: Anesthesia

In brief

Carbon monoxide (CO) is a colorless, odorless, and tasteless gas that exerts diverse biological effects across tissues and organs. At high concentrations, it is recognized as toxic because of harmful effects such as tissue hypoxia, oxidative stress, peroxynitrite formation, inflammation, apoptosis, and immune damage. However, the endogenous production of CO suggests that it may confer protective mechanisms to the host. These protective effects include inhibition of platelet activation, smooth muscle relaxation, vasoactive properties, anti-inflammatory and anti-apoptotic actions, and beneficial influences on neurotransmission. Despite its toxic potential, low-concentration endogenous CO may provide protection linked to the body's defense mechanisms. In this study, we aimed to investigate the anti-apoptotic effects of carbon monoxide at low concentrations. To this end, the relationships between COHb levels and plasma levels of NF-κB, NRF2, and PGC-1α were analyzed statistically.

Key facts

Study ID

NCT07352826

Run by

Ataturk Training and Research Hospital

People needed

120

Starts

2026-02-20

Expected to finish

2026-08-31

Last updated by the study team

2026-01-20

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• aged 18-70 years
• classified as ASA I
• scheduled for inhalational anesthesia lasting ≥2 hours

You may not qualify if…

• Patients with cardiovascular disease, respiratory system disease, hepatic or renal disease
• pregnant or breastfeeding women
• trauma patients
• those undergoing emergency surgery
• procedures lasting <2 hours
• those receiving intraoperative blood transfusion
• smokers
• individuals who decline participation

Where it is running

• Veysel — Erzurum, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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