Combined High-Intensity Aerobic Training and Resistance Training in Psoriatic Arthritis

Starting soon · Not applicable

Conditions studied: Psoriatic Arthritis

In brief

The goal of this randomised controlled trial is to evaluate the effects of a 12-week intervention comprising high-intensity interval aerobic training and strength training on cardiovascular function, metabolic health profile and inflammation in patients with Psoriatic arthritis. A secondary goal is to assess the intervention´s impact on physical fitness, pain, fatigue, and health-related quality of life, and to explore long-term maintenance of exercise following completion of the intervention. We hypothesize that 12 weeks of combined high-intensity interval aerobic training and strength training will improve cardiometabolic health, inflammation, and enhance physical fitness, fatigue, pain and quality of life in Psoriatic arthritis.

Key facts

Study ID

NCT07352696

Run by

Vastra Gotaland Region

People needed

88

Starts

2026-02-02

Expected to finish

2028-12-01

Last updated by the study team

2026-01-22

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Psoriatic arthritis disease according to the CASPAR (Classification Criteria for Psoriatic Arthritis) criteria
• Age range 18-65 years
• Stable medication on anti- rheumatic drugs for >3 months prior to inclusion and throughout the first 3 months of the study

You may not qualify if…

• Cardiovascular disease
• Severe hypertension
• Diabetes type I
• Chronic obstructive pulmonary disease or other severe pulmonary diseases
• Arthroplasty of large joints, lower extremities
• Severe functional impairment precluding participation in high-intensity aerobic exercise
• Inability to perform a cardiopulmonary exercise testing (CPET)
• Pregnancy
• BMI ≥35 kg/m²
• Ongoing or planned initiation (within 3 months) of structured weight reduction therapy, pharmacological obesity treatment, or bariatric bypass surgery
• Already participating in regular exercise at high intensity (BORG ≥15) for >1 hour/ week during the past 6 months
• Inability to understand and read Swedish

Where it is running

• Sahlgrenska University hospital — Gothenburg, Sweden
• Skaraborgs sjukvård, Skövde — Skövde, Sweden

Full record on ClinicalTrials.gov

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