Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery

Recruiting now

Conditions studied: Acute Kidney Injury

In brief

This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery. Urinary biomarkers are intended to be evaluated as predictors of PO-AKI in the same subjects. The study employs modern standardized classifications for AKI to comprehensively address the issue of PO-AKI in children. Describing the incidence and identifying risk factors for PO-AKI will play a crucial role in developing preventive strategies aimed at reducing associated mortality and morbidity. Furthermore, investigating the relationship between urinary biomarkers of renal injury and PO-AKI will provide valuable insights into assessing postoperative renal function in paediatric patients, especially when repeated blood sampling is not feasible.

Key facts

Study ID

NCT07351149

Run by

Uppsala University

People needed

2000

Starts

2026-03-01

Expected to finish

2028-12-31

Last updated by the study team

2026-05-12

Who can join

Age: any, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Elective, urgent or emergency in-patient major non-cardiac surgical procedures performed under general anaesthesia with or without regional analgesia with a planned procedure duration of at least 60 minutes.
• Paediatric patients (0-16 years old)

You may not qualify if…

• Declined participation.
• Ongoing renal replacement therapy
• Acute Kidney Injury (according to KDIGO)
• Known chronic kidney disease
• Procedure involving surgery of the kidney
• Procedures requiring clamping of blood flow to or from the kidney
• Body weight <2kg
• Procedure involving contrast administration
• Established rhabdomyolysis (CK-levels >1500 U/L)

Where it is running

• Uppsala University Hospital — Uppsala, Sweden (enrolling)
• Karolinska University Hospital — Stockholm, Sweden (enrolling)
• Hospital das Clínicas HCFMUSP — São Paulo, Brazil
• Hospices Civils de Lyon — Lyon, France
• IRCCS Istituto Giannina Gaslini — Genova, Italy
• University Hospital of Belgrade — Belgrade, Serbia
• Sahlgrenska University Hospital — Gothenburg, Sweden
• Skåne University Hospital — Lund, Sweden
• University Hospital Basel — Basel, Switzerland
• University Hospital Bern — Bern, Switzerland
• Perth Children's Hospital — Perth, Western Australia, Australia
• University Hospital Geneva — Geneva, Switzerland
• The Kids Research Institute Australia — Perth, Western Australia, Australia

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.