Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Osteo Arthritis of the Knee

In brief

The aim of this clinical randomized trial is to compare local infiltration analgesia (LIA) alone versus the combination of LIA with saphenous nerve (SN) block, block of the nerve to vastus medialis (NVM), and anterior femoral cutaneous nerve (AFCN) block in participants undergoing total knee arthroplasty (TKA). The primary outcome is pain intensity, measured using the Numerical Rating Scale (NRS) at multiple time points after surgery. Secondary outcomes include opioid consumption, time to mobilization, postoperative nausea and vomiting, length of hospital stay, neurological complications and differences in opioid consumption and NRS pain scores between general and spinal anesthesia.

Key facts

Study ID

NCT07350252

Run by

Region Skane

People needed

200

Starts

2026-03-05

Expected to finish

2027-09-01

Last updated by the study team

2026-05-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Undergoing primary unilateral total knee arthroplasty

You may not qualify if…

• Pregnancy
• Coagulopathy or other bleeding disorder that precludes regional anesthesia
• Allergy to local anesthetics
• Inability to understand spoken and written Swedish
• Unwillingness to participate in the study

Where it is running

• Department of Anaesthesiology, Trelleborg Hospital — Trelleborg, Sweden (enrolling)

Full record on ClinicalTrials.gov

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