Pentoxifylline in Patients With Ulcerative Colitis

Recruiting now · Phase 2

Conditions studied: Inflammatory Bowel Diseases

In brief

Ulcerative colitis (UC) is a persistent, idiopathic form of inflammatory bowel disease (IBD) marked by uninterrupted inflammation of the colon's mucosal lining, usually starting at the rectum and progressing proximally in a continuous manner. It manifests clinically with recurrent episodes of abdominal pain, bloody diarrhea, urgency, tenesmus, and weight loss. The precise cause of UC is still unknown; however, it is thought to arise from a multifactorial interaction involving genetic susceptibility, immune system dysregulation, disturbances in gut microbiota composition, and various environmental factors.

Key facts

Study ID

NCT07349472

Run by

Ihab Elsayed Hassan

People needed

60

Starts

2026-01-20

Expected to finish

2027-02-20

Last updated by the study team

2026-04-15

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Both male and female will be included
• Negative pregnancy test and effective contraception.
• Mild and moderate UC patients

You may not qualify if…

• Breast feeding
• Significant liver and kidney function abnormalities
• Diabetic patients
• Colorectal cancer patients
• Patients with severe UC
• Patients taking rectal or systemic steroids
• Patients taking immunosuppressives or biological therapies
• Addiction to alcohol and / or drugs
• Known allergy to the studied medications

Where it is running

• Fayoum University — Al Fayyum, Egypt (enrolling)

Full record on ClinicalTrials.gov

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