Dilute Epinephrine vs Tourniquet for Visualization in Ankle Arthroscopy: A RCT
Starting soon · Not applicable
Conditions studied: Chronic Ankle Instability, Ankle Ligament Injury, Ankle Arthroscopy
In brief
This multicenter, prospective randomized controlled trial investigates the effect of dilute epinephrine irrigation versus tourniquet use on visual field clarity (VFC) during ankle arthroscopy. Patients are randomized into an epinephrine group (normal saline with 1 mL of 1:1000 epinephrine per 3 L bag; tourniquet placed but not inflated unless needed) or a standard tourniquet group. The primary outcome is arthroscopic visual field clarity assessed using a 4-point Likert-style numeric rating scale. Secondary outcomes include postoperative pain intensity at 2 and 24 hours (VAS), and the incidence of hypotension, bradycardia, and cardiovascular adverse events.
Key facts
- Study ID
- NCT07349407
- Run by
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- People needed
- 88
- Starts
- 2025-12-30
- Expected to finish
- 2026-12-30
- Last updated by the study team
- 2026-01-16
Who can join
Age: 15 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Able to understand the procedures and methods of the clinical trial
- voluntarily provide written informed consent
- Aged from 15 to 65 years old , regardless of sex
- Diagnosed with a condition requiring ankle surgery
- Be scheduled to undergo unilateral ankle arthroscopy
You may not qualify if…
- Patients who decline to participate in the study
- Known history of heart disease (e.g., coronary artery disease, cardiac conduction abnormalities), diabetes, or asthma
- Poorly controlled hypertension
- Age under 15 years or above 65 years old
- Intellectual disability
- Pregnant or breastfeeding women
- Known allergy to sulfites
- Contraindications to ISBPB (including planned injection site infection, pre-existing neurological deficits, allergy to local anesthetics, severe chronic obstructive pulmonary disease, or contralateral phrenic nerve dysfunction)
Full record on ClinicalTrials.gov
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