Rubix LS Diabetic Kidney Disease (DKD) Registry Study

Running, not enrolling

Conditions studied: Diabetic Kidney Disease (DKD)

In brief

Diabetic kidney disease (DKD) is a common complication of type 2 diabetes that can lead to kidney failure and increases the risk of cardiovascular disease. This prospective, observational patient registry will follow adults with type 2 diabetes and DKD who are receiving routine clinical care at participating sites, with intentional enrollment from underserved communities. Health information will be collected from medical records and brief questionnaires (including social and access factors) for up to 24 months to understand DKD progression, real-world treatment patterns, and outcomes. This study does not assign any treatment. With participant consent and appropriate privacy safeguards, de-identified registry data may be shared with researchers to accelerate evidence generation and inform future studies focused on improving outcomes.

Key facts

Study ID

NCT07348718

Run by

Rubix LS

People needed

2000

Starts

2025-12-15

Expected to finish

2026-04-01

Last updated by the study team

2026-01-16

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years at the time of enrollment
• Documented diagnosis of type 2 diabetes mellitus in the medical record
• Evidence of chronic kidney disease consistent with diabetic kidney disease (DKD), defined by one or more of the following, with evidence of chronicity (present for ≥3 months based on prior laboratory results, diagnosis codes, or clinician documentation):
• eGFR <60 mL/min/1.73 m², and/or
• Urine albumin-to-creatinine ratio (UACR) ≥30 mg/g
• Receiving ongoing clinical care at a participating site with medical record data available for longitudinal follow-up
• Able and willing to provide written informed consent (and authorization for medical record review, as applicable) and to complete registry questionnaires

You may not qualify if…

• End-stage kidney disease at baseline (maintenance dialysis) or history of kidney transplant
• Type 1 diabetes mellitus
• Known primary kidney disease not primarily attributable to diabetes that, in the investigator's judgment, is expected to drive kidney outcomes (e.g., polycystic kidney disease, active glomerulonephritis, lupus nephritis, vasculitis)
• Inability to provide informed consent or comply with registry procedures (e.g., no feasible longitudinal follow-up through the participating site)

Where it is running

• Rubix LS — Lawrence, Massachusetts, United States

Full record on ClinicalTrials.gov

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