Electrophysiology-based DBS Programming for PD

Recruiting now · Not applicable

Conditions studied: Parkinson's Disease (PD)

In brief

Deep brain stimulation (DBS) effectively alleviates motor symptoms in Parkinson's disease (PD). However, current programming is manual and time-consuming. This study will evaluate physiology-based programming using local field potentials (LFPs) to identify optimal stimulation parameters. Specifically, DBS contact selection based on beta power and a broad-band approach will be compared with conventional clinician-based programming.

Key facts

Study ID

NCT07348705

Run by

University of Florida

People needed

30

Starts

2026-01-15

Expected to finish

2031-01-15

Last updated by the study team

2026-03-30

Who can join

Age: 21 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with a diagnosis of idiopathic PD fulfilling the Movement Disorder Society Clinical Diagnostic Criteria for PD
• DBS implantation with the Percept DBS device (Medtronic, USA) for the treatment of motor symptoms
• Ability to give informed consent for the study
• Willingness to do this study at the time of the initial programming session
• Age 21 to 89 years old

You may not qualify if…

• Inability to comply with the study protocol
• Atypical Parkinsonism
• Any personality or mood symptoms that study personnel believe will interfere with the study requirements

Where it is running

• Norman Fixel Institute for Neurological Diseases — Gainesville, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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