EFESO: Study on Juvenile Onset Eosinophilic Fasciitis
Recruiting now
Conditions studied: Eosinophilic Fasciitis
In brief
Eosinophilic fasciitis is a connective tissue disorder characterized by inflammation of the muscle fasciae, which is very rare in children. In juvenile-onset eosinophilic fasciitis (JEF), there may be severe joint involvement and skin manifestations may be less prevalent than in adults. It represents an important differential diagnosis of both juvenile-onset systemic sclerosis and localized scleroderma, and the correct classification of these patients is necessary to define a targeted diagnostic-therapeutic pathway. The diagnostic criteria proposed for eosinophilic fasciitis in the adult population do not necessarily require confirmation by skin biopsy, currently the "gold standard," which is an invasive procedure for pediatric patients; however, these criteria have never been directly applied to the pediatric population. From a therapeutic point of view, the combination of glucocorticoids and methotrexate is recommended for both adults and pediatric patients, but the data supporting this treatment in children are very limited, and there are no studies comparing the therapeutic approaches currently in use in pediatrics. Finally, there are no studies in the literature documenting the long-term prognosis of these patients in terms of functional limitations, quality of life, or complications related to the disease or treatments.
Key facts
- Study ID
- NCT07348263
- Run by
- Meyer Children's Hospital IRCCS
- People needed
- 20
- Starts
- 2025-05-15
- Expected to finish
- 2027-05-15
- Last updated by the study team
- 2026-03-11
Who can join
Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Age ≥18 years at diagnosis;
- Unwilling to participate into the study;
- A follow-up period < 6 months.
Where it is running
- Iuliu Hatieganu University of Medicine and Pharmacy — Cluj-Napoca, Romania (enrolling)
- Children's Hospital Zagreb — Zagreb, Croatia (enrolling)
- Meyer Children's Hospital IRCCS — Florence, FI, Italy (enrolling)
- Astrid Lindgren Children's Hospital — Solna, Stockholm County, Sweden (enrolling)
- IRCCS Giannina Gaslini, — Genova, Italy (enrolling)
- Alder Hey Children's Hospital — Liverpool, United Kingdom (enrolling)
- University of Alabama at Birmingham — Birmingham, Alabama, United States (enrolling)
- SUNY Upstate Pediatric Rheumatology — Syracuse, New York, United States (enrolling)
- Great North Children's Hospital, Newcastle Upon Tyne — Newcastle upon Tyne, United Kingdom
- Hamburger Zentrum für Kinder- und Jugendrheumatologie - — Hamburg, Germany
- Ruth Rappaport Children's Hospital of Haifa — Haifa, Israel
- Università di Udine — Udine, Italy
- University Children's Hospital — Ljubljana, Slovenia
- Hospital Sant Joan de Déu, — Barcelona, Spain
- Cerrahpasa Medical School, Istanbul University — Istanbul, Turkey (Türkiye)
Full record on ClinicalTrials.gov
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