Characterizing Drug Liking During Drug Administration in Peri-procedural Clinical Settings

Starting soon · Early Phase 1 · Has a placebo group

Conditions studied: Drug Liking

In brief

The purpose of this study is to evaluate whether medications used in peri-procedural clinical settings can modulate drug liking.

Key facts

Study ID

NCT07348172

Run by

Stanford University

People needed

100

Starts

2026-03-01

Expected to finish

2028-03-31

Last updated by the study team

2026-01-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• American Society of Anesthesiologists (ASA) physical status classification of I, II or III
• Candidates who are expected to receive fentanyl up to 3 mcg/kg IBW for their scheduled for surgery or procedure

You may not qualify if…

• Craniofacial abnormalities
• Known or suspected difficult intubation or mask ventilation
• Known or suspected need for rapid sequence induction and intubation
• Allergies or hypersensitivities to amisulpride or fentanyl
• Clinically significant pulmonary disease, such as chronic obstructive lung disease requiring long-term oxygen therapy, or other conditions that, in the study team's judgment, may increase the risk of severe respiratory depression with opioid administration
• History of long QT syndrome
• Any heart rhythm other than normal sinus rhythm (including but not limited to atrial fibrillation, atrial flutter, paced rhythms, ventricular tachycardia, or any supraventricular tachycardia)
• History of Torsades de Pointes
• History of psychosis
• History of movement disorders e.g. Parkinson's Disease
• Past chronic use of anti-psychotics
• Current use of amisulpride, droperidol, levodopa, lithium, clozapine, metoclopramide, benzodiazepines
• Current use of opioids
• History of opiate abuse within the last 3 years
• Known or suspected severe chronic pain condition that require use of opiates or limit daily activities
• History of pheochromocytoma
• History of concomitant prolactin-dependent tumors e.g. prolactinoma, breast cancer
• Pregnancy or nursing
• Failure to satisfy the investigator of fitness to participate for any other reason

Where it is running

• Stanford Hospital — Palo Alto, California, United States

Full record on ClinicalTrials.gov

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