Functional Rehabilitation Effects on Exercise-induced Hypoalgesia in Chronic Low Back Pain

Enrolling by invitation · Not applicable

Conditions studied: Low Back Pain

In brief

Chronic low back pain is a prevalent condition characterized by persistent pain and associated physical and psychosocial limitations. Physical exercise is currently considered a primary treatment to promote positive outcomes in individuals with chronic low back pain. However, pain itself represents a major barrier to regular participation in physical activity. In healthy individuals, exercise induces hypoalgesia, reflected by an increase in pain detection thresholds following physical activity. Enhancing exercise-induced hypoalgesia may promote adherence to regular physical activity in individuals with chronic low back pain. Previous research suggests that regular physical activity may facilitate exercise-induced hypoalgesia through physiological responses associated with exercise that are influenced by physical activity levels. Therefore, interventions centered on physical activity may enhance exercise-induced hypoalgesia in individuals with chronic low back pain, potentially contributing to pain reduction and increased engagement in physical activity. The primary objective of this exploratory study is to evaluate the effects of a four-week functional rehabilitation program, with physical activity as its main component, on exercise-induced hypoalgesia in individuals with chronic low back pain

Key facts

Study ID

NCT07347457

Run by

Clinique de la Mitterie

People needed

51

Starts

2025-11-14

Expected to finish

2027-12-31

Last updated by the study team

2026-01-16

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Voluntary participant
• Able to provide written informed consent
• Aged between 18 and 60 years
• Diagnosed with chronic low back pain, defined as persistent low back pain for at least three months
• Enrolled in the functional rehabilitation program at Les Peupliers Clinic
• Affiliated with a health insurance system

You may not qualify if…

• Presence of a contraindication to physical activity
• Presence of a severe cardiovascular, neurological, or psychiatric condition
• Pregnant or breastfeeding women
• History of alcohol and/or drug addiction
• Individuals under legal guardianship or curatorship
• Individuals in an emergency situation

Where it is running

• Clinique les Peupliers — Villeneuve-d'Ascq, France

Full record on ClinicalTrials.gov

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