Prospective Geometric Analysis of Ultra-Widefield OCTA Characteristics in Central Serous Chorioretinopathy Patients
Starting soon
Conditions studied: Central Serous Chorioretinopathy (CSC)
In brief
By leveraging parameters including fractal dimension and topological index, we constructed a quantitative evaluation framework for ultra-widefield optical coherence tomography angiography (UWF-OCTA) images in patients with central serous chorioretinopathy (CSC), thus overcoming the limitations of conventional qualitative analysis.
Key facts
- Study ID
- NCT07347119
- Run by
- Sun Yat-sen University
- People needed
- 120
- Starts
- 2025-12-18
- Expected to finish
- 2027-06-30
- Last updated by the study team
- 2026-01-16
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults aged 18 to 60 years, inclusive;
- Clinical diagnosis of central serous chorioretinopathy (CSC);
- Completion of fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) examinations;
- Completion of ultra-widefield optical coherence tomography angiography (UWF-OCTA) imaging;
- No prior history of pharmacological or surgical treatment for CSC;
- Ability and willingness to provide written informed consent.
You may not qualify if…
- Presence of other ophthalmic diseases that may affect retinal or choroidal imaging or analysis, including but not limited to: Significant refractive media opacities interfering with OCTA imaging (e.g., severe cataract, vitreous hemorrhage);
- Presence of systemic diseases that may affect study outcomes or participant safety;
- Pregnant or lactating women;
- History of psychiatric or mental disorders that may impair compliance;
- Hemorrhagic diathesis or requirement for long-term anticoagulant therapy;
- History of long-term systemic medication use that may affect choroidal or retinal circulation;
- Presence of severe and/or uncontrolled comorbid medical conditions, including but not limited to:
- Uncontrolled diabetes mellitus; Uncontrolled hypertension; Active uncontrolled infection; Chronic obstructive pulmonary disease (COPD) with dyspnea at rest;
- History of intraocular surgery or intravitreal injection within the past 6 months;
- High refractive error defined as:
- Spherical equivalent (SE) < -6.0 diopters or > +3.0 diopters, or Axial length (AL) > 26.0 mm;
- Any other condition that, in the opinion of the investigator, would make participation unsafe or interfere with protocol adherence.
Where it is running
- Zhongshan Ophthalmic Center, Sun Yat-sen University — Guangzhou, Guangdong, China
Full record on ClinicalTrials.gov
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