Non-invasive Brain Stimulation on Functional Capacity in Prefrail Older Adults

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Prefrail Elderly

In brief

The general objective of this study is to evaluate the effectiveness of non-invasive neuromodulation combined with a therapeutic exercise program on neuroplasticity and, therefore, on variables related to functional capacity and quality of life, in prefrail older adults.

Key facts

Study ID

NCT07346989

Run by

University of Valencia

People needed

80

Starts

2026-01-15

Expected to finish

2028-07-01

Last updated by the study team

2026-07-06

Who can join

Age: 65 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 65 -90 years old
• Meet 1-2 frailty criteria, according to Fried's Criteria.
• Ability to understand instructions (Mini-Mental State Examination >23 points).
• Signing of the informed consent.

You may not qualify if…

• History of stroke within the past 6 months or hospital admission for any reason within the past 3 months.
• Alterations of the central or peripheral nervous system
• Alterations of the vestibular system
• Concomitant diseases
• Have a neurological pathology, cardiovascular musculoskeletal that contraindicates physical activity
• Epilepsy or history, medications that lower the seizure threshold
• Cardiac pacemaker, endocranial and hearing implants
• History of severe headaches
• Uncontrolled intracranial or arterial hypertension
• Heart and/or respiratory failure
• Implanted medication pump
• Skin lesions (psoriasis, eczema)
• Serious head surgeries
• Completing less than 80% of training sessions

Where it is running

• University of Valencia — Valencia, Valencia, Spain (enrolling)

Full record on ClinicalTrials.gov

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