A Study Testing the Effects of Different THC Doses on Psychological and Biological Function

Starting soon · Phase 1 · Has a placebo group

Conditions studied: Evaluate PK Profile, Evaluate PD Profile, Healthy Adults, Safety and Tolerability in Healthy Volunteers

In brief

The goal of this clinical trial is to learn how a investigational medicinal product (THC) affects psychological and physical responses in healthy adults with prior cannabis use experience. The main questions it aims to answer are: \- How do different dose levels of the investigational medicinal product (THC) influence short-term subjective and physiological responses? Researchers will compare three dose levels of the study drug to a placebo (a look-alike substance with no active ingredient) to see how responses vary across sessions. Participants will: * Attend four in-person study visits, each involving a single dose of either the study drug or placebo * Complete questionnaires about their moment-to-moment experiences * Have their heart rate, blood pressure, and other physical measures monitored * Undergo serial blood sampling to measure circulating biomarkers

Key facts

Study ID

NCT07346690

Run by

University of Calgary

People needed

24

Starts

2026-02-01

Expected to finish

2028-02-01

Last updated by the study team

2026-01-16

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults aged 18-55
• No major medical or psychiatric conditions
• At least one previous, well-tolerated experience with cannabis
• Not currently pregnant or breastfeeding

You may not qualify if…

• Family history (first- or second-degree relatives) of bipolar disorder, psychosis, or schizophrenia
• Significant negative reaction to cannabis in the past or known allergy to cannabis products
• Currently using recreational drugs

Where it is running

• University of Calgary, Heritage Medical Research Building — Calgary, Alberta, Canada

Full record on ClinicalTrials.gov

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