IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients
Recruiting now
Conditions studied: Critical Illness, Intensive Care Patients, Critical Illness Requiring Intensive Care - Sepsis, Critical Illness Requiring Intensive Care - Acute Brain Injury, Critical Illness Requiring Intensive Care - Major Surgery, Critical Illness Requiring Intensive Care - Polytrauma
In brief
This is a prospective observational physiopathological study aimed at evaluating the immunological and inflammatory determinants associated with the prognosis of patients admitted to intensive care units (ICU). The study will establish multidimensional models predicting one-year survival and the occurrence of nosocomial infections. Patients admitted to ICU undergo routine biological sampling. In addition to these, minimal supplementary samples will be collected for immunological and inflammatory biomarker analysis at admission, day 1, day 4, day 8, ICU discharge or day 28, and at 12 months. Additional samples may be taken during clinically significant events (nosocomial infections, complications).
Key facts
- Study ID
- NCT07345169
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 540
- Starts
- 2026-01-01
- Expected to finish
- 2031-02-01
- Last updated by the study team
- 2026-01-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Admission to ICU within 24 hours
You may not qualify if…
- Moribund patient (ECOG=4)
- Legal protection (guardianship/curatorship)
- Uninsured patients
- Pre-existing immunosuppression (active/recent cancer, hematologic disease, autoimmune disease, organ transplant, HIV)
- Pregnant or breastfeeding women
- Participation in another interventional trial
- Patients under AME
Where it is running
- AP-HP Laribosière Hospital, Anesthesia and Critical Care Departement — Paris, France (enrolling)
Full record on ClinicalTrials.gov
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