Burning Mouth Syndrome: Effects of Occlusal Splint Therapy

Starting soon · Not applicable

Conditions studied: Burning Mouth Syndrome, Orofacial Pain, Mouth Dryness

In brief

Burning Mouth Syndrome (BMS) causes chronic oral pain and significantly affects quality of life. Effective treatments are limited and often provide only temporary relief. This prospective N-of-1 study evaluates the effect of an intraoral Essix appliance on pain intensity and salivary secretion in patients with BMS. Saliva samples are collected and analysed for volume and composition.

Key facts

Study ID

NCT07344909

Run by

Malmö University

People needed

12

Starts

2026-01-15

Expected to finish

2027-11-01

Last updated by the study team

2026-01-15

Who can join

Age: 18 and older, up to 80. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• patients with oral mucosal pain from participants in the previous BMS validation study.
• greater than 30% pain relief during prior use of an Essix appliance.
• chronic intraoral pain lasting more than 3 months.
• age between 18 and 80 years.

You may not qualify if…

• fibromyalgia
• ongoing dental treatment

Where it is running

• Malmö university — Malmö, Sweden

Full record on ClinicalTrials.gov

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