Blood Flow Restriction Resistance Exercise and Cardiac Cycle Dynamics

Starting soon · Not applicable

Conditions studied: Cardiac

In brief

Blood flow restriction resistance exercise uses partial vascular occlusion of a limb during low weight resistance exercises to stimulate muscle strengthening and growth. This is commonly used during rehabilitation from an injury. Because blood flow in and out of the limbs is decreased, this may have consequences for blood flow through the heart. The purpose of this study will be to test cardiac dynamics during blood flow restriction resistance exercise to determine if cardiac blood flow is impacted. It is hypothesized that both non-BFR exercise and BFR exercise will increase heart rate shortening various cardiac cycle parameters, but BFR exercise will increase the isovolumetric contraction time vs non-BFR exercise due to an increase in total peripheral resistance. It is also hypothesized that BFR exercise will lower early ventricular filling parameters due to lower venous return.

Key facts

Study ID

NCT07344740

Run by

Montclair State University

People needed

40

Starts

2026-02-01

Expected to finish

2028-01-01

Last updated by the study team

2026-02-13

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Generally healthy

You may not qualify if…

• Uncontrolled hypertension
• Peripheral vascular disease
• Lymphedema
• Sickle cell anemia
• Heart failure
• Stroke history
• Heart attack history
• Rheumatoid arthritis
• Chronic kidney disease
• Diabetes
• Severe neuropathy
• Any condition that may make blood flow restriction resistance exercise riskier like history of blood clots
• Use of coagulant therapy
• Susceptible to blood clots
• Obesity

Where it is running

• Montclair State University — Montclair, New Jersey, United States

Full record on ClinicalTrials.gov

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