Factors Associated With Clinical Pregnancy Outcomes in Intrauterine Insemination (IUI) Cycles

Recruiting now

Conditions studied: Reproductive Issues

In brief

Hypotheses: We hypothesize that variations in hormonal profiles (LH, estradiol, progesterone) during ovarian stimulation, follicular response, endometrial characteristics, and sperm quality parameters are significantly associated with clinical pregnancy outcomes in intrauterine insemination (IUI) cycles. Aims * To investigate the association between hormonal profiles on the trigger day (LH, estradiol, progesterone), follicular response, endometrial thickness, and sperm parameters with clinical pregnancy outcomes in IUI cycles. * To develop and validate a predictive model for clinical pregnancy incorporating key determinants such as female age, hormonal response, endometrial characteristics, and sperm quality. * To compare natural and gonadotropin-stimulated IUI cycles in terms of hormonal profiles, pregnancy outcomes, and cost-effectiveness. Primary Outcome Clinical pregnancy rate (CPR), defined as the presence of a gestational sac with a fetal heartbeat on ultrasound at approximately 6 weeks of gestation following intrauterine insemination. Secondary Outcomes * Biochemical pregnancy rate. * Ongoing pregnancy rate * Live birth rate

Key facts

Study ID
NCT07344623
Run by
Chinese University of Hong Kong
People needed
3000
Starts
2026-01-13
Expected to finish
2028-01-01
Last updated by the study team
2026-05-11

Who can join

Age: 18 and older, up to 42. Sex: female. Healthy volunteers: not accepted.

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Where it is running

Full record on ClinicalTrials.gov

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