Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Oral, Melatonin, Pregabalin, Postoperative Pain, Anxiety, Spine Surgery

In brief

This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.

Key facts

Study ID

NCT07344467

Run by

Tanta University

People needed

105

Starts

2026-01-17

Expected to finish

2027-06-01

Last updated by the study team

2026-01-21

Who can join

Age: 21 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 21-60 years old.
• Both sexes.
• Patients of American Society of Anesthesiologists (ASA) physical status I \& II.
• Undergoing elective spine surgery.

You may not qualify if…

• Patient refusal.
• History of allergic reactions to melatonin or pregabalin.
• Patients with cardiovascular disease (ischemic heart disease, Heart Failure, Arrythmia, Heart Block).
• Patients with kidney disease with (plasma creatinine level > 1.5mg/dl).
• Patients with liver disease with (aspartate transaminase, alanine transaminase, and bilirubin levels more than twice the upper limit of normal).
• Psychological and cognitive disorders; dementia; major depression.
• Circadian rhythm disorders such as chronic fatigue syndrome and drowsiness.

Where it is running

• Tanta University — Tanta, El-Gharbia, Egypt (enrolling)

Full record on ClinicalTrials.gov

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