Less is Better? Effectiveness of a Short Local Vibration Protocol on Neuromuscular Function

Recruiting now · Not applicable

Conditions studied: Healthy Volonteers

In brief

Local vibration is a non-invasive neuromuscular stimulation modality used in training and rehabilitation for its effects on neuromuscular function, particularly its ability to induce nervous adaptations. Its passive application is particularly useful in cases of motor deficit or immobilization. Several studies, including our own, have shown that vibration protocols over several weeks can induce significant gains in muscle strength, particularly in the knee extensors. However, the parameters of application remain heterogeneous, particularly with regard to the duration of the interventions. With this in mind, a prospective controlled study is being conducted in healthy subjects, comparing four modalities of local vibration intervention targeting the knee extensors: an intensive vibration protocol over 5 consecutive days (1 session of 30 or 60 minutes per day) and a protocol spread over 4 weeks at a rate of 3 weekly sessions of 30 or 60 minutes). The objective is to evaluate and compare their immediate and delayed effects on force production and corticospinal properties. The results of this study will thus help optimize recommendations regarding the use of local vibration in muscle strengthening and neuromuscular reconditioning strategies.

Key facts

Study ID

NCT07344298

Run by

Centre Hospitalier Universitaire de Saint Etienne

People needed

72

Starts

2026-03-23

Expected to finish

2028-01-22

Last updated by the study team

2026-03-27

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women,
• Aged between 18 and 45,
• With a body mass index between 18 and 30 kg/m²,
• Who have received detailed information about the study and have co-signed the consent form with the investigator,
• Who are affiliated with or entitled to social security coverage.

You may not qualify if…

• Subjects with chronic cardiovascular, neuromuscular, bone, metabolic, and/or inflammatory conditions,
• Personal history and/or risk factors for thrombosis,
• Subjects undergoing antidepressant treatment,
• Subjects who have taken corticosteroid treatment in the last 3 months,
• Use of neuroactive substances likely to alter corticospinal excitability (hypnotics, antiepileptics, psychotropic drugs, muscle relaxants) during the study period,
• History of bone or ligament trauma to the lower limbs within the last 12 months,
• Unable to perform the physical efforts required for the study,
• Engaging in intense and unusual physical activity, including competitive sports, in the month preceding and during the protocol,
• Presence of a skin lesion at the site where the vibrator is to be placed,
• Simultaneous participation in another interventional medical trial,
• Pregnant and breastfeeding women
• Subjects unable to understand the purpose and conditions of the study, unable to give their consent,
• Subjects deprived of their liberty or subject to legal protection such as guardianship

Where it is running

• CHU de Saint-Etienne — Saint-Etienne, France (enrolling)

Full record on ClinicalTrials.gov

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