Investigation of the Impact of Myomectomy on Uterine Artery Doppler Velocimetry Findings
Enrolling by invitation
Conditions studied: Leiomyoma (Uterine Fibroids), Myomectomy, Doppler Ultrasound
In brief
Objective: This scientific study aims to investigate whether myomectomy induces significant changes in uterine artery blood flow patterns. While Doppler ultrasonography is traditionally used to assess myoma vascularity, differential diagnosis (adenomyoma or sarcoma), and fertility impacts, there is a lack of prospective evidence comparing preoperative and postoperative uterine artery Doppler findings. Study Design and Rationale: The study will evaluate the hemodynamic influence of myomectomy by comparing flow measurements in the main uterine artery before and after surgical intervention. Existing literature has primarily focused on the correlation between myoma volume and vascular resistance; however, the direct impact of surgical removal of a myoma on uterine artery doppler velocimetry remains under-investigated. Participant Involvement: Participation is entirely voluntary, and participants may withdraw at any time without any impact on their medical care. Data collection involves routine clinical history, physical examination, and non-invasive ultrasound measurements. Clinical Significance: By establishing the effect of myoma removal on uterine blood supply, this research aims to provide guiding data for the follow-up and treatment planning of patients with leiomyomas. The findings may offer new insights into how surgical management restores or alters uterine hemodynamics, potentially influencing future diagnostic and therapeutic approaches.
Key facts
- Study ID
- NCT07343765
- Run by
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
- People needed
- 70
- Starts
- 2025-09-01
- Expected to finish
- 2026-02-01
- Last updated by the study team
- 2026-01-15
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Premenopausal women aged between 18 and 50 years.
- Women with uterine leiomyoma detected via ultrasonography.
- Patients referred to the Obstetrics and Gynecology department board for whom a myomectomy operation has been decided.
- Women who provide consent for transvaginal ultrasound examination.
You may not qualify if…
- Women under 18 years of age and postmenopausal women.
- Current pregnancy or postpartum status.
- Presence of known circulatory disorders, cardiovascular diseases, or other chronic conditions affecting blood flow.
- Smokers.
- Current use of hormonal medications (e.g., oral contraceptives, levonorgestrel-releasing intrauterine devices, etc.).
- Presence of concurrent gynecological pathologies (e.g., adenomyosis, endometriosis, ovarian cysts, or gynecological malignancies).
Where it is running
- Bakırköy Dr Sadi Konuk Eğitim ve Araştırma Hastanesi — Istanbul, bakırköy, Turkey (Türkiye)
Full record on ClinicalTrials.gov
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