Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study
Recruiting now · Not applicable
Conditions studied: Critical Illness, ICU
In brief
This multicentric randomized controlled trial aims to evaluate whether indirect calorimetry (IC)-guided nutritional support improves patient-centered outcomes in critically ill adult patients compared to standard formula-based nutritional strategies. The study includes mechanically ventilated patients expected to remain in the ICU for more than 72 hours. The intervention group will receive nutritional targets based on measured resting energy expenditure using the QNRG+ device, with a gradual escalation of energy delivery following current ESPEN guidelines. The primary outcome is quality of life at 3 months post-ICU admission, assessed using the EQ-5D-5L. Secondary outcomes include functional recovery, muscle preservation, infection rates, and rehospitalization. This study is the first to assess the long-term impact of IC-guided nutrition on recovery and quality of life using a patient-centered approach.
Key facts
- Study ID
- NCT07343440
- Run by
- HEIDEGGER CP
- People needed
- 356
- Starts
- 2026-01-01
- Expected to finish
- 2027-09-01
- Last updated by the study team
- 2026-05-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All patients admitted to the ICU with the following criteria:
- ≥18 years old
- On Mechanical Ventilation
- Expected ICU length of stay >72 hours
You may not qualify if…
- Refusal of the family or patient
- Patient transferred from another ICU
- Pregnant patient
- Patient is planned for a withdrawal of care or is actively dying
- Cognitive disorder before ICU
- Patient is in jail
- Patients already enrolled in the ongoing NutriPhyT trial
Where it is running
- Geneva University Hospital — Geneva, Switzerland (enrolling)
- GHOL — Nyon, Switzerland (enrolling)
- Zürich University Hospitals — Zurich, Switzerland (enrolling)
Full record on ClinicalTrials.gov
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