Phase Ib/II Study to Evaluate the Safety and Efficacy of IBI363 in Combination With Chemotherapy as Second-Line Therapy for Unresectable Locally Advanced or Metastatic Pancreatic Cancer

Starting soon · Phase 1/Phase 2

Conditions studied: Pancreatic Cancer Metastatic

In brief

This study is an Ib/II phase clinical trial evaluating the safety and efficacy of IBI363 combined with chemotherapy as a second-line treatment for unresectable locally advanced or metastatic pancreatic cancer. Approximately 39-48 patients with unresectable locally advanced or metastatic pancreatic cancer, who have progressed on or are intolerant to first-line chemotherapy (albumin-bound paclitaxel + gemcitabine, AG regimen), will be enrolled. Treatment involves IBI363 combined with chemotherapy and continues until disease progression, death, intolerable toxicity, withdrawal of informed consent, initiation of new antitumor therapy, or other protocol-specified reasons for discontinuation.

Key facts

Study ID

NCT07342725

Run by

Ruijin Hospital

People needed

48

Starts

2026-01-01

Expected to finish

2028-12-31

Last updated by the study team

2026-01-15

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed written informed consent form (ICF)
• Age 18-75 years
• Histologically/cytologically confirmed, unresectable locally advanced or metastatic pancreatic cancer.
• Disease progression or intolerance after first-line treatment with the AG regimen (gemcitabine + albumin-bound paclitaxel).
• ECOG Performance Status(PS) score of 0-1.
• At least one measurable lesion according to RECIST v1.1 criteria.
• Adequate organ and bone marrow function

You may not qualify if…

• Previous histologically/cytologically confirmed components including adenosquamous carcinoma, medullary carcinoma, signet ring cell carcinoma, undifferentiated carcinoma, etc.
• Prior treatment with PD-1/PD-L1 inhibitors or other immunotherapies.
• Unresolved > Grade 1 toxicities related to prior anticancer therapy (except persistent Grade 2 alopecia, anemia, peripheral neuropathy, correctable electrolyte abnormalities, or well-controlled endocrine disorders with hormone replacement therapy).
• History of hepatic encephalopathy, seizures, active/new/untreated CNS metastases, spinal compression, carcinomatous meningitis, or leptomeningeal metastases.
• Clinically significant cardiovascular/cerebrovascular diseases
• Known hypersensitivity to IL-2, sintilimab, or monoclonal antibody components

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.