A Dose-Escalation Study of RO7875913 in Healthy Participants
Recruiting now · Phase 1 · Has a placebo group
Conditions studied: Healthy Volunteers
In brief
The purpose of this study is to evaluate the safety, pharmacokinetics, and pharmacodynamics of RO7875913 in healthy participants.
Key facts
- Study ID
- NCT07342114
- Run by
- Genentech, Inc.
- People needed
- 40
- Starts
- 2026-03-11
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-07-20
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Agreement to adhere to the contraception requirements
- Body weight > 40 kilogram (kg) with a body mass index of 18-30 kg per meter square (kg/m\^2)
You may not qualify if…
- Positive test result for hepatitis B surface antigen, hepatitis C virus (HCV), or human immunodeficiency virus (HIV) antibody screen
- History of any malignancy
- Major surgical procedure within 28 days prior to initiation of study treatment, or anticipation of need for a major surgical procedure during the study
- History or clinical manifestations of significant metabolic, hepatic, renal, pulmonary, cardiovascular, hematologic, gastrointestinal, urologic, neurologic, or psychiatric disorders
- Known allergy or hypersensitivity to any component of the RO7875913 formulation
- Treatment with investigational biologic therapy (or blinded comparator) within 90 days or 5 drug elimination half-lives, whichever is longer, prior to initiation of study drug
- Treatment with investigational non-biologic therapy (or blinded comparator) within 28 days or 5 drug elimination half-lives, whichever is longer, prior to initiation of study drug
- Treatment with any immunosuppressive medication within 28 days or 5 drug elimination half-lives, whichever is longer, prior to initiation of study drug
Where it is running
- New Zealand Clinical Research - Christchurch — Christchurch, Canterbury, New Zealand (enrolling)
Full record on ClinicalTrials.gov
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