Coordinated Reset Deep Brain Stimulation for Parkinson's Disease

Starting soon · Phase 1

Conditions studied: Parkinson's Disease (PD), Deep Brain Stimulation

In brief

Deep brain stimulation (DBS) is a surgical implant procedure for the treatment of Parkinson's Disease (PD) utilizing medical devices approved by the FDA. A novel approach to current DBS approaches is called "Coordinated Reset" DBS (CR-DBS) which uses different patterns of stimulation at lower currents and can address the limitations of traditional DBS (T-DBS) that uses continuous high amplitude and high frequency stimulation. This study will evaluate the safety and short-term efficacy of CR-DBS in PD. The results from this study will significantly advance the development of CR-DBS for the treatment of PD. Findings in this study will also provide the rationale for further development of this novel DBS approach for other neurological and psychiatric disorders.

Key facts

Study ID: NCT07340073
Run by: University of Minnesota
People needed: 24
Starts: 2026-09-01
Expected to finish: 2031-07-01
Last updated by the study team: 2026-07-10

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Diagnosis of Idiopathic Parkinson's Disease
Minimum age of 21 years old
Will be or has been implanted with the Boston Scientific Vercise Genus Rechargeable DBS system

You may not qualify if…

History of musculoskeletal disorders that affect movement of the limbs/gait
Other significant neurological disorder
Significant psychiatric disorder
History of dementia or cognitive impairment that precludes them from getting DBS surgery or per study staff judgment, MacCAT-CR assessment does not deduce that the participant has capacity to consent
Other significant medical disorder that could impede study participation
Pregnant women

Full record on ClinicalTrials.gov

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