AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Obesity
In brief
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Key facts
- Study ID
- NCT07339423
- Run by
- Novo Nordisk A/S
- People needed
- 1150
- Starts
- 2026-02-24
- Expected to finish
- 2029-08-21
- Last updated by the study team
- 2026-07-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Clinical Neuroscience Solution — Orlando, Florida, United States (enrolling)
- Hope Clin Res & Wellness — Conyers, Georgia, United States (enrolling)
- Endeavor Health — Skokie, Illinois, United States (enrolling)
- Midwest Inst For Clin Res — Indianapolis, Indiana, United States (enrolling)
- StudyMetrix Research LLC — City of Saint Peters, Missouri, United States (enrolling)
- New York Gastroenterology Associates — New York, New York, United States (enrolling)
- UNC Eastowne Medical Office — Chapel Hill, North Carolina, United States (enrolling)
- PharmQuest Life Sciences LLC — Greensboro, North Carolina, United States (enrolling)
- Accellacare and KDCILM, LLC — Wilmington, North Carolina, United States (enrolling)
- UPA Ctr Weight and Eating Dis — Philadelphia, Pennsylvania, United States (enrolling)
- Clinical Res Collaborative — Cumberland, Rhode Island, United States (enrolling)
- Medical Uni of SC Charleston — Charleston, South Carolina, United States (enrolling)
- Coastal Carolina Research Ctr — North Charleston, South Carolina, United States (enrolling)
- Hillcrest Clinical Research — Simpsonville, South Carolina, United States (enrolling)
- Amarillo Medical Specialists — Amarillo, Texas, United States (enrolling)
- Velocity Clinical Res-Dallas — Dallas, Texas, United States (enrolling)
- Care United Research, LLC — Forney, Texas, United States (enrolling)
- Washington Cntr Weight Mgmt — Arlington, Virginia, United States (enrolling)
- Health Res of Hampton Roads — Newport News, Virginia, United States (enrolling)
- Selma Medical Associates — Winchester, Virginia, United States (enrolling)
- Rainier Clin Res Ctr Inc — Renton, Washington, United States (enrolling)
- Fundación CESIM — Santa Rosa, La Pampa Province, Argentina (enrolling)
- Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli — Buenos Aires, Argentina (enrolling)
- Instituto de Investigaciones Clínicas Córdoba — Córdoba, Argentina (enrolling)
- South Broward Research LLC — Miramar, Florida, United States (enrolling)
Full record on ClinicalTrials.gov
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