IAT-MeVO Trial Domain Within the ACT-GLOBAL Adaptive Platform Trial

Starting soon · Not applicable

Conditions studied: Acute Ischemic Stroke Due to Medium-vessel-occlusion

In brief

IAT-MeVO is an international, multicenter, prospective, randomised, open-label, blinded end-point assessed (PROBE) trial, to evaluate the efficacy and safety of endovascular therapy (EVT) \[intra-arterial thrombolysis (IAT)-based\] versus best medical management (BMT) in patients with acute ischemic stroke (AIS) due to medium vessel occlusion (MeVO) who are ineligible for intravenous thrombolysis (IV) within 24 h of onset.

Key facts

Study ID

NCT07336927

Run by

Bo Wu

People needed

614

Starts

2026-01-01

Expected to finish

2030-12-31

Last updated by the study team

2026-01-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 y;
• Diagnosed as acute ischemic stroke;
• Isolated medium distal vessel occlusion (i.e. an occlusion of the M2, the M3/M4 segment of the MCA, the A1/ A2/A3 segment of the ACA or the P1/P2/P3 segment of the PCA) confirmed by CT or MR Angiography;
• Time from onset (or last-seen-well) to randomization < 24h;
• Has not received intravenous thrombolysis and is considered unsuitable for it based on the treating clinician's assessment.
• NIHSS ≥ 5, or NIHSS ≤ 4 with disabling deficit (e.g. severe aphasia, hemianopia, hemiplegia/loss of function in one side) or fluctuating symptoms at the time of randomization;
• For patients within 6 h of onset: No visually apparent hypodensity is observed on non-contrast CT compared with the contralateral white matter, or no hyperintensity is seen on fluid-attenuated inversion recovery (FLAIR) imaging; For patients presenting 6-24 h after onset: A perfusion imaging-based ischemic core mismatch ratio >1.2 and an infarct core volume <50 mL are required;
• Pre-stroke mRS ≤ 1；
• Patient/Legally Authorized Representative has signed the Informed Consent form.

You may not qualify if…

• Any evidence of intracranial hemorrhage on qualifying imaging;
• Concurrent multiple (≥2) intracranial arterial occlusions;
• Suspected cerebral vasculitis, septic embolism, or infective endocarditis as the cause of vessel occlusion;
• Suspected arterial dissection;
• Clinical assessment of conditions unsuitable for interventional therapy (e.g., severe contrast agent allergy or absolute contraindications to iodine contrast agent; severe renal insufficiency, glomerular filtration rate < 30ml/min or serum creatinine > 220μmol/L (2.5 mg/dl));
• Unsuitable for arterial thrombolytic therapy (e.g., known history of hereditary or acquired hemorrhagic disease and/or platelet count <50×109/L; abnormal coagulation function (INR>1.7); oral anticoagulants were taken within 24 - 48 hours before onset within APTT > 3 times normal; recent medical history or clinical manifestations of brain tumors other than meningiomas);
• Any terminal disease with life expectancy <1 year;
• Pregnancy or lactation;
• Concurrent participation in another investigational drug or device study that could interfere with the present trial;
• Other circumstances that participation is not deemed appropriate.

Where it is running

• West China Hospital of Sichuan University — Chengdu, Sichuan, China

Full record on ClinicalTrials.gov

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