Effect of Vitamin A Supplementation on Idiopathic Scoliosis
Recruiting now · Not applicable
Conditions studied: Vitamin A Deficiency, Idiopathic Scoliosis
In brief
This study aims to investigate whether vitamin A supplementation can influence spinal curve magnitude in idiopathic scoliosis children and potentially prevent its de novo development.
Key facts
- Study ID
- NCT07335991
- Run by
- Second Affiliated Hospital of Wenzhou Medical University
- People needed
- 140
- Starts
- 2025-05-13
- Expected to finish
- 2028-06-01
- Last updated by the study team
- 2026-05-15
Who can join
Age: 6 and older, up to 15. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age between 6 and 15 years.
- Biochemically confirmed vitamin A deficiency (serum retinol < 0.20 mg/L) or insufficiency (serum retinol 0.20-0.29 mg/L).
- Has undergone radiographic evaluation (standing full-spine X-ray) for idiopathic scoliosis at the initial clinic visit.
- Skeletally immature (Risser sign 0-3) with a major Cobb angle < 40 degrees at baseline.
- Written informed consent/assent provided by the participant and legal guardian.
You may not qualify if…
- Unwillingness or inability to comply with all study procedures and follow-up visits.
- Plans to relocate outside the study area within the next 24 months.
- Previous high-dose vitamin A supplementation therapy within the past 12 months.
- Clinical signs of severe vitamin A deficiency syndrome (e.g., xerophthalmia, Bitot's spots).
- Serum vitamin A level > 0.70 mg/L (to avoid risk of hypervitaminosis A).
- Severe chronic health conditions that could confound study outcomes, including but not limited to:
- Known syndromic, neuromuscular, or congenital musculoskeletal causes of scoliosis.
- History of spine surgery or significant spinal trauma.
- Spinal tumor.
- Leg length discrepancy > 20 mm.
- Other severe chronic diseases (e.g., poorly controlled diabetes, chronic liver or renal disease, malabsorption syndromes).
- Severe obesity (body mass index z-score ≥ 3).
Where it is running
- The Second Affiliated Hospital of Wenzhou Medical University — Wenzhou, Zhejiang, China (enrolling)
Full record on ClinicalTrials.gov
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