Early General Anesthesia to Limit Experiences of Trauma During Cesarean Section-Pilot Study
Recruiting now · Not applicable
Conditions studied: Cesarean Section, Delivery; Trauma
In brief
Some patients who undergo cesarean section under spinal or epidural anesthesia can experience severe pain. Some patients who experience this kind of pain can experience symptoms of post-traumatic stress disorder (PTSD) after pregnancy. Currently, the two main options for treating this pain are general anesthesia (full medically induced unconsciousness) and using intravenous medications to reduce the pain and decrease anxiety. The EAGLET-CS Pilot is a pilot randomized trial that will test the feasibility of comparing the impact of these two options for preventing PTSD in a rigorous way for those patients who experience pain during their cesarean section after the baby is out.
Key facts
- Study ID
- NCT07334418
- Run by
- University of Pennsylvania
- People needed
- 600
- Starts
- 2026-04-06
- Expected to finish
- 2027-11-01
- Last updated by the study team
- 2026-06-11
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Women aged 18 or older undergoing non-emergent cesarean delivery with primary neuraxial (epidural, spinal, or CSE) anesthesia. Eligible patients will be those who report severe pain during surgery, defined as pain that does not resolve with 2 trials of first-line pharmacologic therapies (e.g., epidural supplementation with local anesthetics; intravenous opioid analgesics).
You may not qualify if…
- We will exclude patients who require induction of general anesthesia prior to umbilical cord clamping and by clinician determination.
Where it is running
- Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
Full record on ClinicalTrials.gov
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