Extracorporeal Blood Purification Using Oxiris for Septic Shock (EXPLORE Study)
Starting soon · Not applicable
Conditions studied: Septic Shock, Multi Organ Failure
In brief
The goal of this clinical trial is to evaluate if a blood purification treatment called "Oxiris" works to help adults with septic shock. The main questions it aims to answer are: (1) Does Oxiris treatment lower the risk of death or organ failure within the first 7 days? (2) Does Oxiris treatment lower the level of inflammation in the body? Researchers will compare participants who receive Oxiris treatment to a group of participants who receive standard medical care to see if Oxiris helps them recover better. Participants will: 1. Receive blood purification therapy using the Oxiris filter for up to 3 days while in the intensive care unit (ICU). 2. Have their blood tested at the start of the study and 3 days later to check for inflammation and organ function. 3. Be followed by the research team for about 30 days to check on their health and recovery.
Key facts
- Study ID
- NCT07334327
- Run by
- Pusan National University Yangsan Hospital
- People needed
- 62
- Starts
- 2026-02-01
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-01-14
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Participants must be 19 years of age or older.
- Participants must be diagnosed with septic shock (a severe body-wide response to infection that leads to dangerously low blood pressure).
- Participants must be in a condition where the medical team has decided that blood purification therapy (like CRRT) is necessary.
You may not qualify if…
- People who have a "Do Not Resuscitate" (DNR) order or are not expected to survive more than 24 hours.
- People who are pregnant or breastfeeding.
- People who are known to be allergic to the materials used in the Oxiris filter (such as heparin or specific plastics).
- People who are already participating in another clinical trial that might affect the results of this study.
- People whom the doctor decides are not suitable for the study for other medical safety reasons.
Full record on ClinicalTrials.gov
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