Retrolaminar Analgesia for LuMbar Surgery
Recruiting now · Not applicable
Conditions studied: Postoperative Pain, Lumbar Surgery, Back Pain Lower Back Chronic, Opioid Analgesia, Regional Anaesthesia
In brief
This randomized controlled trial evaluates the effectiveness of ultrasound-guided retrolaminar nerve block in addition to standard multimodal analgesia for postoperative pain management in patients undergoing lumbar spine surgery. Fifty patients will be randomly assigned to receive either the retrolaminar block combined with standard pain management or standard pain management alone. The primary outcome is total opioid consumption in the first 24 hours after surgery. Secondary outcomes include pain intensity at multiple time points, time to first rescue analgesia, duration of sensory block, incidence of postoperative nausea and vomiting, length of hospital stay, patient satisfaction, and chronic pain development at 3 and 6 months follow-up.
Key facts
- Study ID
- NCT07334288
- Run by
- Universidad de los Andes, Chile
- People needed
- 50
- Starts
- 2026-03-01
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-04-13
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients aged 18-80 years
- Scheduled for elective lumbar spine surgery (with instrumentation)
- American Society of Anesthesiologists (ASA) physical status I-III
- Willing and able to provide written informed consent
- Able to use patient-controlled analgesia (PCA) device
You may not qualify if…
- Refusal to participate in the study
- Known allergy to local anesthetics (bupivacaine - levobupivacaine - lidocaine) or any study medication
- Contraindication to regional anesthesia (infection at injection site, coagulopathy)
- Chronic opioid use (daily use for >3 months prior to surgery)
- Severe psychiatric disorder that precludes informed consent
- Emergency surgery
- Diabetes mellitus with preoperative glucose >180 mg/dl
- Pregnancy or breastfeeding
- Body mass index (BMI) >40 kg/m²
- Reoperation or revision of the same level of previous spinal surgery
Where it is running
- Clínica Universidad de los Andes, Chile — Santiago, Santiago Metropolitan, Chile (enrolling)
Full record on ClinicalTrials.gov
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