Cold Water Irrigation Therapy as an Adjunct to Indomethacin for Post-Endoscopic Retrograde Cholangiopancreatography(ERCP) Pancreatitis

Recruiting now · Not applicable

Conditions studied: Pancreatitis, ERCP Surgery

In brief

This study is designed to learn whether rinsing the papilla with cold water at the end of an ERCP procedure, in addition to standard medicine, can help lower the chance of developing pancreatitis, which is the most common major complication after ERCP.

Key facts

Study ID

NCT07330284

Run by

University of Kansas Medical Center

People needed

950

Starts

2025-12-05

Expected to finish

2029-12-01

Last updated by the study team

2026-05-07

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Native papilla present.
• Undergoing ERCP for diagnostic or therapeutic indications.
• Able to provide informed consent.

You may not qualify if…

• Post-operative reconstructed intestinal tract other than Billroth I reconstruction.
• Acute pancreatitis at the time of ERCP.
• Chronic pancreatitis.
• Pancreatic head cancer with occlusion of the main pancreatic duct.
• Existing pancreatic duct stent or need for prophylactic pancreatic duct stenting during the index ERCP.
• Known contraindications or allergy to indomethacin or other NSAIDs.
• Significant renal impairment (eGFR < 30 mL/min/1.73m²).
• Active peptic ulcer disease or history of NSAID-induced gastrointestinal bleeding.

Where it is running

• University of Kansas Cancer Center — Kansas City, Kansas, United States (enrolling)

Full record on ClinicalTrials.gov

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