The Effectiveness of Nano Bio Fusion Gingival Gel (NBF) on Wound Healing at the Palate (Donor Site) After Soft Tissue Graft Surgery Compared to Placebo Gel.

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Wound Healing, Palatal Wound, Donor Site Complication, Inflammatory Cytokines

In brief

The goal of this clinical trial is to assess the effect of Nano-biofusion gingival gel (NBF) on wound healing at the palatal donor site following soft tissue graft surgery and compare it to placebo gel. The main questions it aims to answer are: * Does NBF gel enhance wound healing after graft harvesting from the palate? * Does NBF gel reduce the number of inflammatory mediators after surgery? * Does NBF gel reduce pain and discomfort at the palatal donor site? Researchers will compare NBF gel to a placebo (a look-alike gel that does not contain the active ingredients) to see if NBF gel enhances wound healing. Study steps include: * Participants will apply the assigned gel on the surgical wound 4 times a day for 4 weeks. * Clinical photographs and measurements will be obtained on days (0, 1, 2, 4, 7, 15, 21, 30). * Wound fluid samples will be collected on days (0, 1, 2, 4, 7). * Participants will be asked about the level of pain and analgesic consumption on each follow-up visit.

Key facts

Study ID

NCT07330154

Run by

King Abdullah University Hospital

People needed

36

Starts

2025-10-29

Expected to finish

2026-12-01

Last updated by the study team

2026-01-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with gingival recession that is indicated for root coverage or need for phenotype modification.
• 18 years or older.
• absence of systemic disease
• Non-smoker
• No use of antibiotics, corticosteroids, anti-inflammatory medication or hormones in the past 3 months

You may not qualify if…

• Pregnant or lactating woman.
• patients with immune or systemic diseases.
• Patients with an allergy to any ingredient in the gel.

Where it is running

• Jordan University of Science and Technology, Faculty of Dentistry — Irbid, Irbid Governorate, Jordan (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.