Dexamethasone, Dexmedetomidine and Their Combination on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy

Recruiting now · Not applicable · Has a placebo group

Conditions studied: GIT Function, Cholecystectomy, Laparoscopic, Dexamethasone, Dexmedetomidine, I-FEED Score

In brief

The goal of this clinical trial is to learn the effect of Dexamethasone and Dexmedetomidine and Their Combination on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy What medical problems do participants have when taking Dexamethasone and Dexmedetomidine? Researchers will compare Dexamethasone and Dexmedetomidine and Their Combination to a placebo (a look-alike substance that contains no drug) to see the effect on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy Participants will receive Dexamethasone 8 mg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia. Participants will receive Dexmedetomidine 0.5 mcg /kg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia. Participants will receive Dexamethasone 8 mg IV + Dexmedetomidine 0.5 mcg/kg IV+ Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia. Participants will receive Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia

Key facts

Study ID

NCT07329933

Run by

Benha University

People needed

160

Starts

2025-12-15

Expected to finish

2026-08-01

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• . Age 18-65 years.
• American Society of Anesthesiologists (ASA) physical status I or II.
• Scheduled for elective laparoscopic cholecystectomy surgery under general anesthesia.
• Ability to provide written informed consent

You may not qualify if…

• Known allergy or contraindication to any study drug (dexamethasone, dexmedetomidine, or placebo).
• Pre-existing gastrointestinal motility disorders (e.g., gastroparesis, inflammatory bowel disease).
• Chronic use of opioids, steroids, or antiemetics.
• History of severe cardiac disease (e.g., high-grade AV block, severe bradycardia).
• Uncontrolled diabetes mellitus (HbA1c > 8.0%).
• Emergency surgery or conversion to open surgery.
• Pregnancy or breastfeeding.
• Morbid obesity (BMI >40).
• Severe hepatic or renal dysfunction.

Where it is running

• Benha University Hospital — Banhā, Egypt (enrolling)

Full record on ClinicalTrials.gov

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