Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee Osteoarthritis

Recruiting now · Not applicable

Conditions studied: Knee Osteoarthristis

In brief

Evaluation of intra-articular injections in knee osteoarthritis using frozen-stored PRP. Compared with intra-articular injections of PRP applied at the time of collection.

Key facts

Study ID

NCT07329361

Run by

MiKS Hospital

People needed

60

Starts

2025-12-16

Expected to finish

2027-12-31

Last updated by the study team

2026-01-09

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients of both sexes.
• Aged between 40 and 85 years old.
• Diagnosed with osteoarthritis through clinical radiological examination.
• Joint pain equal to or less than 75 points on the KOOS (pain).
• Radiological severity grades 1, 2, and 3 according to the Ahlbäck scale.
• Indication for intra-articular PRP infiltration.
• Body Mass Index values between 20 and 35.
• Negative serological tests for syphilis, HIV, HBV, and HCV.
• Possibility of observation during the follow-up period.
• Signature of informed consent.

You may not qualify if…

• Body mass index >35
• Diagnosed polyarticular disease.
• Previous arthroscopy in the last year.
• Severe mechanical deformity.
• Intra-articular hyaluronic acid injection in the last 12 months.
• Intra-articular corticosteroid or PRP injection in the last 6 months.
• Systemic autoimmune rheumatic disease (connective tissue diseases and systemic necrotizing vasculitis).
• Anemia or other hematological disorders.
• Positive serological tests for SYPHILIS, HIV, HBV, and HCV.
• Undergoing immunosuppressive treatments.
• Poorly controlled diabetes mellitus.
• Patients allergic to paracetamol.
• Pregnancy or breastfeeding.

Where it is running

• Arthroscopic Surgery Unit, MiKS Hosptial — Vitoria-Gasteiz, Araba/Álava, Spain (enrolling)

Full record on ClinicalTrials.gov

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