Reducing Mobility-associated Interruption in HIV Treatment in Malawi

Recruiting now · Not applicable

Conditions studied: HIV

In brief

The goal of this pilot clinical trial is to assess the feasibility and acceptability of an intervention package designed to reduce mobility-associated interruptions in HIV treatment in people living with HIV in Malawi who are initiating or returning to antiretroviral treatment (ART) after interruption. The main questions it aims to answer are: * Is the intervention acceptable to healthcare workers and ART clients? * Is the intervention feasible in the context of Malawi's health system, and what are the major operational challenges, resource requirements, and implementation barriers? In addition, researchers will compare HIV treatment outcomes (specifically ART retention rates) between intervention and control groups to establish a preliminary estimate of the intervention's efficacy. Participants will complete a survey on the day of enrollment and some participants will complete an in-depth interview and/or a survey after completion of the 6-month follow-up period. Facilities assigned to the intervention group will receive the full package of interventions (training on mobility-specific counseling for counsellors, access to a toll-free hotline for clients and healthcare workers, and training on multi-month dispensing for providers), while facilities assigned to the control group will provide standard of care.

Key facts

Study ID

NCT07329166

Run by

University of California, Los Angeles

People needed

400

Starts

2025-12-18

Expected to finish

2027-02-01

Last updated by the study team

2026-01-09

Who can join

Age: 15 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 15 years of age or older
• Living with HIV
• Attending ART clinic to initiate OR re-initiate care:
• Initiate: initiating ART for the first time, per self-report
• Re-initiate: returning to care after missing a refill appointment by >28 days

You may not qualify if…

• Attending ART clinic on behalf of someone else (i.e. guardian)
• Attending ART clinic only to obtain emergency refill
• Attending ART clinic for a routine refill without a recent >=28 days interruption in treatment
• Transferring in to study facility without a preceding interruption in treatment of >=28 days

Where it is running

• Partners in Hope — Lilongwe, Malawi (enrolling)

Full record on ClinicalTrials.gov

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