Isoleucine Addition Treatment Effects in a Controlled Diet Study

Withdrawn before enrolling · Not applicable · Has a placebo group

Conditions studied: Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS), Obesity & Overweight

In brief

The primary purpose of this study is to determine whether isoleucine repletion attenuates increases in insulin sensitivity typically observed when people with obesity follow a healthy, low-isoleucine diet.

Key facts

Study ID

NCT07329088

Run by

Jean L. Fry

People needed

0

Starts

2026-05-04

Expected to finish

2029-01-31

Last updated by the study team

2026-04-15

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• BMI ≥ 30
• Meeting at least three metabolic syndrome criteria
• Follow an American style diet

You may not qualify if…

• Type 1 or 2 Diabetes diagnosis
• Medical condition or medication that affects insulin sensitivity, weight, or metabolism
• More than 5% weight change in 3 previous months
• Restrictive dietary pattern
• History of bariatric surgery
• Food allergy more severe than grade 1 on the CoFAR Grading Scale for Systemic Allergic Reactions, Version 3.0
• Allergy to lidocaine.

Where it is running

• University of Kentucky — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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