Effect of Titrated Administration of Ciprofol on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial

Recruiting now · Not applicable

Conditions studied: Hypotension During Surgery

In brief

Elderly patients are frequently burdened with age-associated comorbidities and frailty, accompanied by physiological changes such as vascular stiffening, cardiac dysfunction, and impaired autonomic regulation. These factors not only increase the risk of adverse perioperative outcomes but also heighten sensitivity to anesthetic agents, making elderly patients particularly susceptible to anesthesia-related complications, especially hypotension. Consequently, optimizing anesthesia strategies for this high-risk population has become a critical goal in perioperative management. Titrated anesthesia, which individualizes anesthetic drug delivery based on patient response to achieve predefined endpoints, offers a potential approach to mitigating anesthetic risks. Ciprofol, a novel intravenous anesthetic, has been associated with less hemodynamic suppression compared with traditional agents; however, higher single doses may still predispose patients to hypotension. Remifentanil, an ultra-short-acting opioid, exerts significant cardiovascular depressive effects, further contributing to perioperative hypotension. It is hypothesized that titrated administration of anesthetic agents during both the induction and maintenance phases, compared with conventional fixed-dose protocols, may reduce the incidence of perioperative hypotension in elderly patients.

Key facts

Study ID: NCT07328958
Run by: Sixth Affiliated Hospital, Sun Yat-sen University
People needed: 500
Starts: 2026-01-16
Expected to finish: 2027-01-30
Last updated by the study team: 2026-06-10

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age ≥65 years, scheduled for elective laparoscopic abdominal surgery
American Society of Anesthesiologists (ASA) physical status I-III
Requirement for invasive arterial blood pressure monitoring

You may not qualify if…

Participation in other clinical trials that may interfere with the intervention or outcomes of this study
Severe hepatic or renal disease (GFR ≤30 mL/min/1.73 m², requirement for renal replacement therapy, or Child-Pugh class C liver function)
Uncontrolled severe hypertension (preoperative SBP ≥180 mmHg or DBP ≥110 mmHg)
Patients with severe mental disorders (such as schizophrenia), epilepsy, or Parkinson's disease, severe cognitive or intellectual impairment, severe visual or hearing impairments affecting assessment, or long-term alcohol abuse or use of sedative/analgesic medications;
Known allergy to drugs used in this study
Requirement for continuous vasopressor infusion before surgery, or intraoperative need for prolonged hemodynamic manipulation due to surgical factors
Anticipated blood loss >15% of estimated blood volume
Expected surgical duration <1 hours or >6 hours
Expected postoperative hospital stay <72 hours

Where it is running

Sixth Affiliated Hospital, Sun Yat-sen University — Guangzhou, Guangdong, China (enrolling)
Sixth Affiliated Hospital, Sun Yat-sen University — Guangzhou, Guangdong, China

Full record on ClinicalTrials.gov

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