Neurobiological and Genomic Predictors of Relapse in Depression

Recruiting now

Conditions studied: Healthy, Major Depressive Disorder (MDD)

In brief

The goal of this observational study is to test whether the discontinuation of antidepressant medications for patients with depression can be decided after the normalization of biological parameters. The main questions it aims are: 1. When patients with depression treated with antidepressants, does their brain activity also become normal? If so, 2. Then, can we stop the antidepressant treatment and expect minimum repeat of depression? The participants who receive a specific antidepressant treatment will be asked to: * Undergo quantitative electroencephalography (qEEG), * Record Event-related potential (ERP), * Record Sleep EEG * Answer Hamilton Depression Rating Scale question their psychiatrists asked * Give blood sample for genetic analysis * Repeat the above mentioned procedures for at least 3 times during their treatment period. Researchers will compare the results of patients with the results of healthy controls.

Key facts

Study ID

NCT07328373

Run by

Mehmet Kemal Arikan

People needed

204

Starts

2025-01-01

Expected to finish

2027-02-01

Last updated by the study team

2026-01-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Outpatients
• For patients, satisfying Major Depressive Disorder for Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR)
• Drug-free for at least 1-week

You may not qualify if…

• Any neurological and psychiatric comorbid conditions
• Hearing loss
• Physical diseases

Where it is running

• Prof. Dr. Kemal Arıkan's Psychiatry Clinic — Istanbul, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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