Exercise Induced Hypoalgesia in Pain-free Stroke and Healthy Populations: a Cohort Study
Recruiting now · Not applicable
Conditions studied: Stroke, Pain, Exercise Induced Hypoalgesia
In brief
Exercise has shown multiple beneficial effects in both healthy and post-stroke populations. One of these is the acute reduction in sensitivity to painful stimuli, called exercise-induced hypoalgesia (EIH). This phenomenon has been studied since 1979 and has shown improvements in pain thresholds with both aerobic and resistance training in healthy, pain-free populations and different chronic pain conditions. Although there has been extensive research on EIH in healthy populations and those with chronic musculoskeletal pain, surprisingly little attention has been given to individuals with neurological pathologies. Chronic pain is found in more than 50% of patients after stroke, and 70% of affected individuals experience pain on daily activities. Reported prevalences of post-stroke pain (PSP) between different studies, but there is a general consensus that it is an underreported phenomenon. Patients with pain experience greater cognitive and functional decline, fatigue, depression and lower quality of life. Multiple factors contribute to PSP, and various approaches exist to treat all the variables influencing it. This study aims to compare the effects of exercise on pain perception in healthy individuals and stroke patients without pain, using the same cardiovascular training protocol, to better understand the mechanisms of EIH and its maintenance after stroke, ultimately aiming to improve the treatment of people with stroke.
Key facts
- Study ID
- NCT07327593
- Run by
- Neuron, Spain
- People needed
- 60
- Starts
- 2026-04-01
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2026-03-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy cohort:
- Age > 18 years
- No neurological damage
- No medical conditions that could affect the test
- Post-stroke cohort:
- Age > 18 years
- Ischemic or hemorrhagic stroke (time since onset > 3 months)
You may not qualify if…
- Healthy cohort:
- Any medical condition that could affect the test (respiratory, cardiovascular, metabolic diseases, for example)
- Pain in any location, of duration > 1 week in the 3 months preceding the trial.
- Post-stroke cohort:
- Unable to participate in the test (no possibility of transfer or active pedaling)
- Medical contraindication to cardiovascular training for any reason
- Inability to follow instructions or communicate sensations during training
- Other neurological pathology, cardiac pathology (unstable angina, arrhythmias, aortic or left ventricular problems, myocarditis, pericarditis), pulmonary pathology that affects the test (pulmonary embolisms, pulmonary hypertension, etc.), renal or metabolic problems (severe renal dysfunction, uncontrolled diabetes, etc.), acute infection or fever, neurosurgery within 6 weeks prior to inclusion in the study
- Pain in any location, lasting > 1 week in the 3 months prior to the trial.
- Use of beta-blockers, antidepressants, or any medication that may alter heart rate measurements
Where it is running
- Neuron Madrid Río — Madrid, Madrid, Spain (enrolling)
- Neuron Nuevos Ministerios — Madrid, Madrid, Spain (enrolling)
Full record on ClinicalTrials.gov
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