Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)
Recruiting now
Conditions studied: Cancer, Immunotherapy, Advanced Solid Tumors Cancer, Bladder Cancer, TNBC, Triple Negative Breast Cancer, Colorectal Cancer, DMMR Colorectal Cancer, MSI-H Colorectal Cancer, Endometrial Cancer, Head and Neck Cancer, Kidney Cancer, Liver Cancer, NSCLC (Non-small-cell Lung Cancer), Skin Cancer, Melanoma (Skin Cancer)
In brief
This study will collect tumor specimens with correlated clinical and demographic data from patients who are undergoing a biopsy or similar procedure to obtain tumor tissue as a normal course of their medical management or diagnostic work-up for suspected or confirmed cancer.
Key facts
- Study ID
- NCT07327489
- Run by
- Elephas
- People needed
- 2000
- Starts
- 2025-04-14
- Expected to finish
- 2038-04-01
- Last updated by the study team
- 2026-06-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Able and willing to provide informed consent for participation
- Age ≥18 years at time of consent.
- Have a suspected or confirmed cancer diagnosis that is to be evaluated by means of a biopsy.
- Subjects who are newly diagnosed or have suspected cancer must be treatment-naïve at the time of biopsy. All other subjects should have the biopsy performed before starting their next line of treatment.
You may not qualify if…
- Have a known auto-immune disease or prior condition (prior organ transplant, chronic kidney or liver disease) that renders them ineligible for immunotherapy (IO) treatment.
- Severely immunocompromised person(s). Examples include patients on immunosuppressants, HIV positive patients on antiretrovirals, post transplantation patients.
- Pregnant person(s).
Where it is running
- Mercy Hospital - FTS — Fort Smith, Arkansas, United States (enrolling)
- Frederick Health Hospital — Frederick, Maryland, United States (enrolling)
- Mercy Hospital - SPG — Springfield, Missouri, United States (enrolling)
- Mercy Hospital - South — St Louis, Missouri, United States (enrolling)
- Mercy Hospital -STL — St Louis, Missouri, United States (enrolling)
- Mercy Hospital - OKC — Oklahoma City, Oklahoma, United States (enrolling)
- JPS Health Network — Forth Worth, Texas, United States (enrolling)
- Baylor Scott and White Biorepository — Temple, Texas, United States
Full record on ClinicalTrials.gov
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