The Effect of Exercise on Serum Irisin Levels and Clinical Parameters in Patients With Axial Spondyloarthritis.

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Conditions studied: Ankylosing Spondylitis (AS), Irisin

In brief

This study aimed to investigate the effects of high-intensity intermittent exercise and moderate-intensity continuous exercise on serum irisin levels, disease activity, functional status, and quality of life in patients with axial spondyloarthritis.

Key facts

Study ID

NCT07327073

Run by

Kirsehir Ahi Evran Universitesi

People needed

75

Starts

2026-01-30

Expected to finish

2026-05-30

Last updated by the study team

2026-01-12

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients diagnosed with axillary spondyloarthropathy according to ASAS diagnostic criteria,
• Having a high disease severity (ASDAS-CRP above 2.1),
• Being sedentary (not engaging in physical activity at least 3 days a week in the last 3 months),
• Having no change in ankylosing spondylitis medical treatment in the last 3 months,
• Not having any orthopedic, neurological, cardiovascular, or mental disease that would affect exercise,
• Not using any assistive devices for ambulation,
• Having a BMI of 25 kg/m2 or less,
• Male and female patients aged 18-50 years.

You may not qualify if…

• Those with uncontrolled cardiopulmonary disease (such as hypertension, chronic obstructive pulmonary disease, heart failure),
• Having comorbidities that reduce exercise capacity,
• Pregnancy,
• Malignancy,
• Those with a recent history of surgery,
• Those who have engaged in regular exercise (aquatic exercise, land exercise, etc.) in the previous 3 months

Where it is running

• Kırşehir Ahi Evran Üniversitesi — Kırşehir, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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