The Study of ENB With Ultra-thin Cryobiopsy in the Diagnosis of Peripheral Pulmonary Nodules

Enrolling by invitation · Not applicable

Conditions studied: Diagnosis

In brief

To investigate the safety and efficacy of ultrafine cryoprobe biopsy by electromagnetic navigation bronchoscopy compared with biopsy forceps in the diagnosis of peripheral pulmonary nodules in a national multicenter randomized controlled trial

Key facts

Study ID

NCT07326072

Run by

Beijing Chao Yang Hospital

People needed

228

Starts

2025-09-05

Expected to finish

2027-07-31

Last updated by the study team

2026-01-13

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age 18 to 90 years;
• pulmonary nodules detected by chest CT, suspected malignant nodules or unknown cause should be confirmed by biopsy;
• chest CT showed that the nodule was located in the segmental bronchus and below, and the maximum diameter of the nodule was 8 mm to 30 mm.It was not accessible by conventional bronchoscopy;
• if chest CT showed multiple pulmonary nodules, one of the pulmonary nodules was selected as the target lesion.

You may not qualify if…

• contraindications to the bronchoscopy procedure;
• high risk of bleeding, such as bronchial artery penetration or suspected lung metastasis of renal cell carcinoma;
• electromagnetic source implanted in the body;
• contraindications to anesthesia;
• pregnant woman;
• participated in other studies within three months and did not withdraw or finish, affect the observation of this study;
• inability or unwillingness to provide informed consent or comply with the follow-up schedule.

Where it is running

• Beijing Chaoyang Hospital — Beijing, Beijing Municipality, China

Full record on ClinicalTrials.gov

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